食品科学2012，Vol.33Issue(12)：190-195,6.
平行定量浓缩仪-超高效液相色谱-串联质谱联用快速检测鳗鱼中8种喹诺酮类药物残留量
Rapid Simultaneous Determination of Eight Quinolone Residues in Eel by Syncore Analyst-Ultra Performance Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry
摘要
Abstract
A method for the simultaneous determination of eight quinolone residues in eel was developed by syncore analyst- ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry （SA-UPLC-MS/MS）. Deuterium substituted reagents were added as internal standards before sample extraction with acidified acetonitrile, followed by concen- tration using a Syncore Analyst and clean-up with hexane. Eight quinolone residues were analyzed by UPLC-MS/MS under positive ion mode. The limit of detection of the method for eight quinolones was 0.5 ta g/kg, and the limit of quantification was 1.0 lag/kg. The calibration curves showed good linearity over the concentration range of 2.5-200 ng/mL （r 〉 0.99）. The average recovery rates were 81.4% - 11.1% across three spike levels （n = 6）. This method was simple, rapid, stable, reliable, sensitive and suitable for the determination of bulk aquatic products.关键词
平行定量浓缩仪/超高效液相色谱-串联质谱/奎诺酮/鳗鱼/残留量Key words
Syncore Analyst/ultra performance liquid chromatography-electrospray ionization tandem mass spectrometryqunolones~ eel~ residues分类
化学化工引用本文复制引用
张宪臣,华洪波,张朋杰,王勇,杨芳,李蓉,胡仪光,卢俊文..平行定量浓缩仪-超高效液相色谱-串联质谱联用快速检测鳗鱼中8种喹诺酮类药物残留量[J].食品科学,2012,33(12):190-195,6.基金项目
广东省自然科学基金项目 （）
中山市科技计划项目 （）
广东检验检疫局科技计划项目 （）
