食品工业科技2012，Vol.33Issue(17)：127-130,4.
泥鳅ACE抑制肽的体外活性研究
Activity of angiotensin- I-converting enzyme inhibitory peptide from loach （ Misgurnus anguillicaudatus） proteins in vitro
摘要
Abstract
The aim of this study was to investigate the stability of angiotensin-I-converting enzyme inhibitory peptide from loach.The ACE inhibitory activity of loach peptide（ 〈 2.5ku） didn＇ t decrease after 2h heating below 80℃ and remained at high active stability from pH2.0 to 8.0.Based on evaluation of ACE inhibitory activity, freeze drying was better than spray drying.Mg2＋ promoted the angiotensin-I-converting enzyme inhibitory activity,while the Zn2＋ and Mn2＋ inhibited the angiotensin-I-converting enzyme inhibitory activity. Effect of glucose on the angiotensin-I-converting enzyme inhibitory activity significantly was greater than sucrose.With the increase of glucose concentration,the ACE inhibition activity gradually decreased and browned greater.Sodium chloride had no significant effect on antihypertensive activity. Peptides exhibited higher angiotensin-I-converting enzyme inhibitory activity hydrolysis by pepsin, but lower angiotensin-I-converting enzyme inhibitory activity after further hydrolysis by trypsin.Loach peptide belonged to the substrate type of ACE inhibitor.关键词
泥鳅/降血压肽/活性稳定性Key words
loach (Misgurnus anguillicaudatus)/angiotensin - I- converting enzyme inhibitory peptide/active stability分类
轻工纺织引用本文复制引用
李莹,曾晓雄,周剑忠,黄开红,张丽霞,刘小莉..泥鳅ACE抑制肽的体外活性研究[J].食品工业科技,2012,33(17):127-130,4.基金项目
江苏省科技支撑项目（SBE201037924）. （）
