中国食物与营养2012，Vol.18Issue(7)：63-65,3.
白花蛇舌草对HepG2人肝癌细胞Bcl-2和Caspase-3表达的影响
Effects of Hedyotis diffusa on the Expression Hepatoma HepG2 of Bcl-2 and Caspase-3 in Human Cell
摘要
Abstract
[Objective] To study the expression of Bcl-2 and Caspase-3 in human hepatoma HepG2 cell after treatment with extract of Hedyotis diffusa （EHD）. [Method] The anti-proliferative effect of EHD on HepG2 was assessed by MTT assay, and the expression of Bcl-2 and Caspase-3 were observed by immunohistochemical staining. [Result] Compared to control group, EHD could significantly decrease Bcl-2 expression and increase Caspase-3 expression in a dose and time dependent manners. [Conclusion] The downregulation of Bcl-2 and upregulation of Caspase-3 expression may be responsible for the anti-proliferative and apoptosis of HepG2 after treatment with EHD.关键词
白花蛇舌草/HepG2细胞/Bcl-2/Caspase-3Key words
Hedyotis diffusa/HepG2 cell/Bcl-2/Caspase-3分类
生物科学引用本文复制引用
王春涛,王晓东,韩彦龙,辛木梓..白花蛇舌草对HepG2人肝癌细胞Bcl-2和Caspase-3表达的影响[J].中国食物与营养,2012,18(7):63-65,3.基金项目
牡丹江医学院科研项目“白花蛇舌草体外诱导HEPG2人肝癌细胞凋亡及其机制研究”（项目编号：2008-07）. （）
