黄芩素对肝癌H22荷瘤小鼠的抑瘤作用研究OACSCDCSTPCD
Anti-tumor Effects of Baicalein on H22 Hepatocarcinoma-bearing Mice
目的:研究黄芩素对肝癌H22荷瘤小鼠的抑瘤作用.方法:以H22肝癌细胞接种于正常小鼠左前肢腋窝皮下复制肝癌 H22荷瘤模型.实验分为模型对照、环磷酰胺(30 mg·kg-1)和黄芩素高、中、低剂量(80、40、20 mg·kg-1)组.灌胃给药,每天1次连续15d.末次给药后处死小鼠,剥离完整的肿瘤组织称重,并计算肿瘤抑制率;流式细胞仪分析细胞周期分布和凋亡率;按试剂盒说明书测定肿瘤组织中半胱氨酸蛋白酶(Caspase)-3的活性；RT-PCR测…查看全部>>
OBJECTIVE: To investigate the anti-tumor effects of baicalein on H22 hepatocarcinoma-bearing mice. METHODS: H22 tumor-bearing mice model was induced by H22 cell vaccination in normal mouse forelimb left axillary subcutaneous. H22 hepatocarcinoma-bearing mice model was induced and randomized into 5 groups: model control group, cytoxan group (30 mg·kg-1), baicalein high-dose,medium-dose and low-dose groups (80,40,20 mg·kg-1)- They were given medicine intragast…查看全部>>
崔琨;范公忍;姬胜杰;侯保全
商丘市长征人民医院肝病科,河南商丘476000北京军区总医院肝病研究所,北京100700商丘市长征人民医院肝病科,河南商丘476000商丘市长征人民医院肝病科,河南商丘476000
医药卫生
黄芩素肝癌抗肿瘤细胞凋亡
Baicalein Hepatocarcinoma Antitumor Cell apoptosis
《中国药房》 2012 (31)
2897-2899,3
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