北京工商大学学报：自然科学版2012，Vol.30Issue(4)：59-63,5.
土霉素盐酸盐在不同溶剂中溶解度的测定与关联
Measurement and Correlation of Solubilities of Oxytetracycline Hydrochloride in Different Solvents
王立志 1刘庆芬 2刘俊果1
作者信息
- 1. 河北科技大学生物科学与工程学院,河北石家庄050018 河北省发酵工程技术研究中心,河北石家庄050018
- 2. 中国科学院过程工程研究所生化工程国家重点实验室,北京100190
- 折叠
摘要
Abstract
The solubilities of oxytetracycline hydrochloride in short-chain alcohols, including methanol, ethanol, isopropyl alcohol and normal butanol,which were determined by equilibrium method in the tem- perature of 0-55℃. The results show that solubilties in short-chain alcohol with trace water and trace calcium are higher than those in pure short chain alcohol. Besides, the effects of trace water and trace calcium chloride on the solubility were studied in order to close to the solvent system in industry. The sol- ubilities obtained were correlated with the mathematic model of empirical polynomial equation and the semiempirical equation. Using these two equations, the calculated solubilities are in great agreement with the experimental data, and the correlation results of polynomial equation are better than those of semiem- pirical equation. The solubility data and their correlation equations obtained in this study provide valuable data for the recovering and purifying oxytetracycline hydrochloride.关键词
溶解度/溶解度模型/土霉素盐酸盐/短链醇Key words
solubility/solubility model: oxvtetracvcline hvdrochloride : short-chain alcohol分类
轻工纺织引用本文复制引用
王立志,刘庆芬,刘俊果..土霉素盐酸盐在不同溶剂中溶解度的测定与关联[J].北京工商大学学报：自然科学版,2012,30(4):59-63,5.
