A型胰岛素抵抗综合征发病机制的研究进展OACSTPCD
Recent Progress in the Pathogenesis of Type A Insulin Resistance Syndrome
A型胰岛素抵抗综合征(TAIRS)是一种罕见类型的胰岛素抵抗综合征,常染色体隐性遗传,是由于胰岛素受体基因突变影响胰岛素与胰岛素受体结合,造成胰岛素功能障碍,引发一系列生理和病理异常最终产生的疾病.临床上较少见,以严重的胰岛素抵抗、高胰岛素血症、雄激素增多症及黑棘皮病为特点.目前尚无明确的诊断标准,现报道的病例主要根据其临床症状及胰岛素受体基因检测进行诊断.治疗上无根治性手段,以改善胰岛素抵抗、缓解症状为主.
As a rare type of autosomal recessive inheritanced insulin resistance syndrome,type A insulin resistance syndrome (TAIRS) is caused by mutations in the insulin receptor gene which induces insulin dysfunction and a series of physiological and pathological abnormalities due to defective binding of insulin to its receptors. Rarely diagnosed clinically, TAIRS is mainly characterized by severe insulin resistance,hyperinsulinemia.hyperandrogenism,and acantho…查看全部>>
王冠怡
214023 江苏省无锡市,南京医科大学附属无锡人民医院内分泌科
受体,胰岛素胰岛素抗药性雄激素增多症多囊卵巢综合征A型胰岛素抵抗综合征
Receptor,insulinInsulin resistanceHyperandrogenismPolycystic ovary syndromeType A insulin resistance syndrome
《国际妇产科学杂志》 2012 (5)
495-498,4