食品科学2012，Vol.33Issue(15)：283-286,4.
滁菊总黄酮对大鼠心肌缺血再灌注损伤的影响
Effect of Total Flavonoids from Dendranthema morifolium (Ramat) Tzvel. cv. Chuju Flowers on Myocardial Ischemia Reperfusion Injury in Rats
摘要
Abstract
Objective: To observe the effect and underlying mechanism of total flavonoids extracted from Dendranthema morifolium(Ramat) Tzvel.cv.Chuju flowers on myocardial ischemia reperfusion injury(MIRI) in rats.Methods: Acute MIRI mouse models were created by reperfusion for 60 min after anterior interventricular branch of the left coronary artery for 30 min.The infarction area of myocardium,serum creatine kinase(CK) and lactate dehydrogenase(LDH) activities,SOD activity in serum and myocardium,and MDA content in serum and heart tissue were determined.Thrombus length,dry and wet weight of thrombi,and viscosity of whole blood and plasma were also evaluated.Results: Total flavonoids rom Dendranthema morifolium(Ramat) Tzvel.cv.Chuju flowers could decrease the infarction area of myocardium,reduce serum CK and LDH activity,improve the activity of SOD in serum and heart tissue,decrease MDA content in serum and heart tissue,reduce thrombus length,wet weight and dry weight of thrombi in vitro,and improve the viscosity of whole blood.Conclusion: Total flavonoids from Dendranthema morifolium(Ramat) Tzvel.cv.Chuju flowers can protect against MIRI in rats.关键词
滁菊总黄酮/Wistar大鼠/心肌缺血再灌注损伤/脂质过氧化Key words
total flavonoids from Dendranthema morifolium(Ramat) Tzvel.cv.Chuju flowers/Wistar rat/myocardial ischemia reperfusion injury/lipid preoxidation分类
医药卫生引用本文复制引用
俞浩,肖新,刘汉珍,周金星,马世堂,张孝林..滁菊总黄酮对大鼠心肌缺血再灌注损伤的影响[J].食品科学,2012,33(15):283-286,4.基金项目
安徽省自然科学基金项目 （）
科技部科技人员服务企业行动项目 （）
安徽科技学院稳定人才项目 （）
