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水溶性壳聚糖有序聚集体作VC药物载体的研究

李振 王仲妮 周武 刘峰 汤晓露

食品科学2012,Vol.33Issue(17):30-34,5.
食品科学2012,Vol.33Issue(17):30-34,5.

水溶性壳聚糖有序聚集体作VC药物载体的研究

Ordered Assemblies of Water-Soluble Chitosan as Carriers for Vitamin C

李振 1王仲妮 1周武 1刘峰 2汤晓露1

作者信息

  • 1. 山东师范大学化学化工与材料科学学院,农药医药中间体清洁生产教育部工程研究中心,山东济南250014
  • 2. 山东省分析测试中心,山东济南250014
  • 折叠

摘要

Abstract

Two ordered assemblies of water-soluble chitosan were formed in aqueous solution at various chitosan concentrations and temperatures. Steady and dynamic rheological properties of both assemblies were investigated at different temperatures. Meanwhile, the effect of both assemblies as separate carriers for vitamin C on sustained release and stability of vitamin C was determined. The steady rheological curves indicated that both assemblies had strong pseudoplastic property. The dynamic rheological curves revealed that the assembly I could be fitted with Maxwell model under the condition of low frequency and performed as an elastomer under the condition of high frequency. In the tested frequency range, the loss modulus(G ″) of the assembly II was always lower than its storage modulus(G ′ ) . Therefore, both assemblies allows sustained release and stability maintenance of vitamin C.

关键词

水溶性壳聚糖/有序聚集体/流变性质/VC/缓释

Key words

water-soluble chitosan/ordered assembly/rheological property/vitamin C/sustained release

分类

化学化工

引用本文复制引用

李振,王仲妮,周武,刘峰,汤晓露..水溶性壳聚糖有序聚集体作VC药物载体的研究[J].食品科学,2012,33(17):30-34,5.

基金项目

国家自然科学基金项目 ()

食品科学

OA北大核心CSCDCSTPCD

1002-6630

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