中国食品添加剂Issue(4)：158-165,8.
叶黄素咀嚼片毒理学安全性评价
Toxicology and safety assessment of lutein chewable tablets
朱金林 1许新德 1孙晓霞 1王超英 1王有芳 1胡利东1
作者信息
- 1. 浙江医药股份有限公司新昌制药厂,新昌312500
- 折叠
摘要
Abstract
Objective; To evaluate the toxicological safety of lutein chewable tablets. Methods: according to the national standards of Food toxicological assessment issued by Healthy Ministry of PRC, theacute toxicity, genotoxicity tests (Ames test, bone marrow cell micronucleus, sperm shape abnormality) and thirty days feeding test were carried out. Results: The acute toxicity result shows that the biggest tolerance dose of lutein chewable tabletson different sex ICR mice was more than 20. Og/kgbw. The results fell into the scale of non — toxicity. Three genotoxicity tests ( Ames test, bone marrow cell micronucleus, sperm shape abnormality) were all negative. The results of test on feeding for 30 days showed that there were no evident influence on the clinic experiment, hematology, biochemistry, the weight and coefficient of visceral organ and several indexes of pathological organization under the experiment dosage range of 0. 19＞ 0. 38、 0. 75g/kg bw (which were 20, 50 and 100 times separately of recommended absorption for human groups a day) . Cone lusion; lutein chewable tablets is very safe.关键词
叶黄素/咀嚼片/毒理学/安全性/评价Key words
lutein/ chewable tablets/ toxicology/ safety/ assessment分类
轻工纺织引用本文复制引用
朱金林,许新德,孙晓霞,王超英,王有芳,胡利东..叶黄素咀嚼片毒理学安全性评价[J].中国食品添加剂,2012,(4):158-165,8.
