茶叶科学2012，Vol.32Issue(6)：471-479,9.
Caco-2细胞模型在茶叶生物活性成分研究中的应用
Application of Caco-2 Cell Model in the Research of Tea Bioactive Components
谢艳兰 1郭昊蔚 1郑羡慕 1须海荣 1Wilfried Andlauer 2Agnieszka Kosi(n)ska2
作者信息
- 1. 浙江大学农业与生物技术学院茶学系,浙江杭州310058
- 2. Life Technologies Institute, University of Applied Sciences Valais(HES-SO), Sion, CH-1950, Switzerlan
- 折叠
摘要
Abstract
Caco-2 cell monolayer possesses the similar morphological and functional properties to the human intestinal epithelial cells, is one of the important in vitro cell models to study nutrients or drugs absorption, transport and metabolism. In recent years the Caco-2 cell model also widely used in the research of tea bioactive components. The absorption and transport mechanisms of catechins, theanine, gallic acid and caffeine, the metabolism of catechins and the pharmacodynamic mechanism of tea bioactive components in Caco-2 cells were reviewed. What's more, the rapid assessment of tea bioactive components' absorption features using Caco-2 cell model in order to promote the development of tea-care products and preparations were prospected.关键词
Caco-2细胞模型/茶叶/生物活性成分/吸收和转运/代谢/药效机理/综述Key words
Caco-2 cell model, tea, bioactive components, absorption and transport, metabolism, pharmacodynamic mechanism, review分类
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谢艳兰,郭昊蔚,郑羡慕,须海荣,Wilfried Andlauer,Agnieszka Kosi(n)ska..Caco-2细胞模型在茶叶生物活性成分研究中的应用[J].茶叶科学,2012,32(6):471-479,9.
