食品工业科技2012，Vol.33Issue(24)：403-405,409,4.
大剂量牛磺酸对小鼠自主活动能力的影响
Effect of large-dose taurine on locomotor activity of mice
陈文 1张静 1张艳贞 1郭月逸1
作者信息
- 1. 北京联合大学应用文理学院,生物活性物质与功能食品北京市重点实验室,北京100191
- 折叠
摘要
Abstract
In order to study the effect of large-dose taurine on locomotor activity of mice , 8 -weeks -old male BALB/C mice were divided into 3 groups:control group,taurine group 1 (250mg/kg. bw),and taurine group 2 (500mg/kg .bw) based on their body weights. 10d later,open-field test,elevated plus-maze test and tail suspension trial were conducted. Open-field test results:compared with control group,taurine group 1 and 2 had more locomotive activity in both of periphery and central area(p〈0.05),and had less immobility time(%) (p〈0.05) ,and had prolonged slow-moving and fast-moving time(%)(p〈0.05). Elevated plus-maze test results- compared with control group,the percentage of time in open arms was markedly increased in taurine group 1 (p〈0.05),and both of the percentage of time and moving distance in open arms were significantly improved in taurine group 2(p〈0.05). Tail suspension trial results :there were no differences on immobility time,and total energy and power of movement among three groups. All the above data suggested taurine improved the iocomotive activity and exploring ability of mice,and showed some anxiolytic effect but no antidepression effect.关键词
牛磺酸/旷场实验/高架十字迷宫实验/尾悬挂实验/小鼠Key words
taurine/open-field test/elevated plus-maze test/tail suspension trial/mice分类
轻工纺织引用本文复制引用
陈文,张静,张艳贞,郭月逸..大剂量牛磺酸对小鼠自主活动能力的影响[J].食品工业科技,2012,33(24):403-405,409,4.
