食品科学2012，Vol.33Issue(21)：298-302,5.
葛根素通过调控炎性因子水平降低营养性肥胖大鼠的体质量
Weight Loss Effect of Puerarin in Diet-Induced Obese Rats by Regulating Inflammatory and Anti-inflammatory Cytokines
摘要
Abstract
The purpose of the present study was to explore the effects of puerarin on weight loss and obesity-related cytokines in rats with diet-induced obesity.Male Sprague-Dawley(SD) rat models of diet-induced obesity were created and randomly divided into three groups: obesity model group,sibutramine positive control group and puerarin treatment group.In addition,a normal control group was set up.Each group consisted of 6 rats and was intragastrically administrated once daily for 42 consecutive days.During the administration period,body weight was measured once a week.Each group was fasted for 24 h after the last administration,and then anaesthetized with diethyl ether for blood sampling from the retro-orbital plexus and routine blood indexes and the levels of glucose(Glu),insulin,leptin,adiponectin,tumor necrosis factor-alpha(TNF-α),vascular endothelial growth factor(VEGF) and triglycerides(TG) in the serum of rats were assayed.After puerarin administration for 42 days,body weight was reduced by 21% when compared with the control group.The levels of Glu,low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),insulin,leptin,VEGF and TNF-α were decreased by 16%,20%,58%,12%,70%,36% and 36%,respectively.The levels of high-density lipoprotein cholesterol(HDL-C) and adiponectin were increased by 26% and 16%,respectively.Therefore,puerarin can inhibit the increase of body weight,reduce the levels of LDL-C,Glu,insulin and leptin,increase the concentrations of HDL-C and adiponectin,elevate the levels of anti-inflammatory cytokines,inhibit inflammatory cytokines,and improve insulin resistance and leptin resistance in obese rats.关键词
葛根素/肥胖/细胞因子/大鼠Key words
puerain/obesity/cytokine/rats分类
医药卫生引用本文复制引用
王雪青,宋文军,李长文,白晓丽,侯红件,何长江..葛根素通过调控炎性因子水平降低营养性肥胖大鼠的体质量[J].食品科学,2012,33(21):298-302,5.基金项目
云南天士力生物茶科技有限公司资助项目 （）
