中国食品学报2012，Vol.12Issue(10)：24-28,5.
金枪鱼鱼油对D-半乳糖致衰老小鼠学习记忆的作用
Effects of Tuna oil on Learning and Memory in Senile Mice Induced by D-galactose
摘要
Abstract
Objective: To investigate the effects of tuna oil on learning and memory in senile mice induced by D— galactose(Gal). Melhod: 72 mice were divided randomly into six groups: normal control(NC), model control(MC), positive control (PC), low dose(LD), medium dose(MD), high dose(HD). NC with normal saline [ 1 000 mg/(kg·d) ], while the others were treated with D-galactose[1 000 mg/(kg·d)) by subcutaneous injection. NC and MC were given I.g. Normal saline (10 mL/kg bw), LD,MD and HD groups were given I.g 10 mL/kg bw tuna oil respectively 20 mg/mL、 50 mg/mL and 100 mg/mL. PC were treated with piracetam [200 mg/(kg·d) ]. After six weeks, learning and memory ability in mice were evaluated by Morris water maze and Y-maze. Their brains were dissected out after Y-maze experiment for detecting the level of MDA, the activity of SOD and GSH-Px. Results: Compared with MC, the escape latency was obviously shortened, and the ratio of swimming time and distance in platform region in Morris water maze was increased, correct times were increased in Y-maze, time of electronic shock was shortened, the activity of SOD and GSH-Px was increased and the level of MDA was decreased of mice treated with tuna oil at different dose. Moreover, the high—dose group exhibited the similar effects with the piracetam-treated group. Conclusion; Tuna oil can improve learning and memory of senile mice induced by D—galactose.关键词
金枪鱼鱼油/D-半乳糖/衰老/学习记忆Key words
iuna oil/ D—galactose/ senile/ learning and memory引用本文复制引用
王霞,苏秀榕,黄健,李妍妍,赵凤敏,曹福生,王求娟,陈义方,夏静波,徐嘉杰..金枪鱼鱼油对D-半乳糖致衰老小鼠学习记忆的作用[J].中国食品学报,2012,12(10):24-28,5.基金项目
宁波市科技局农业与社发重大科技项目(2010C10040) （2010C10040）
宁波市教育局重点学科资助项目(szxl1070) （szxl1070）
