现代食品科技2013，Vol.29Issue(1)：8-10,28,4.
青梅提取物防治氧嗪酸钾致小鼠高尿酸血症的研究
Study on the Prevention and Treatment of Prunus mume Extracts against Potassium Oxonate Induced Hyperuricemia in Mice
摘要
Abstract
This paper mainly studied the prevention and treatment of ethyl acetate fraction of Prunus mume seed extract (PMS-E) and n-butanol fraction of Prunus mume flower extract (PF-B) against potassium oxonate (uncase inhibitor) induced hyperuricemia in mice. The serum uric acid level of mice was measured by alkaline phosphotungstate method; serum biochemical indexes, such as creatinine, urea nitrogen and albumin and globulin ratio, and xanthine oxidase (XO) in serum and liver were measured by corresponding kit. The results indicated that the serum uric acid level in middle and high dose groups of PMS-E and PF-B significantly lower than hyperuricemic group (p<0.01); PF-B and PMS-E could decrease the serum creatinine and urea nitrogen levels significantly, but had no significantly influence on albumin and globulin ratio (p>0.05). In addition, PMS-E and PF-B could inhibit XO activity in serum and liver significantly. This study laid a foundation for Prunus mume extracts exploitation to functional foods and dietary supplements for lowering uric acid and anti-gout.关键词
青梅/高尿酸血症/尿酸酶抑制剂/功能性评价Key words
Prunus mume Sieb. et Zucc/hyperuricemia/uncase inhibitor, functional evaluation引用本文复制引用
夏道宗,潘东曼,龚金炎,邵奇佳..青梅提取物防治氧嗪酸钾致小鼠高尿酸血症的研究[J].现代食品科技,2013,29(1):8-10,28,4.基金项目
浙江省农产品化学与生物加工技术重点实验室开放基金(2010KF0516) （2010KF0516）
国家自然科学基金(81102861) （81102861）
浙江省教育厅科研项目(Y201016348) （Y201016348）
