食品与机械2013，Vol.29Issue(1)：76-80,5.DOI:10.3969/j.issn.1003-5788.2013.01.017
呋喃西林代谢物在凡纳滨对虾体内代谢及残留
Pharmacokinetics and residues of metabolite of nitrofurazone (semicarbazide) in Penaeus vannamei
摘要
Abstract
Pharmacokinetics and residues of metabolite of nitrofura-zone(semicarbazide, SEM) were investigated in Penaeus vannamei, under experimental field conditions at (28±2)℃ after oral multi-dose administration (30 mg/kg). The concentrations of SEM in plasma and tissues were determined by using high performance liquid chromatography-tandem mass spectrometry(LC-MS/MS) after liquid-liquid extraction and analyzed by software of WinNonlmS. 2 and Excel 2010. Compartmental analysis showed that the half-life of absorption (t1/2 K01), distribution (t 1/2α) and elimination (t 1/2β) were 0. 695, 2. 567 and 47. 603 h, respectively. Non-compartmental analysis based on statistical moment theory showed that the mean residence time (MRT) of SEM in plasma, muscle, gill, hepatopancreas and intestine were 34. 424, 49.281, 39,178, 32. 390 and 35. 17 h, respectively. At the 2th day post-treatment, the SEM half-lives of elimination phase in muscle, plasma, gill, hepatopancreas and intestine were 11. 75, 8. 88, 8. 66, 5. 37 and 4. 71 d, respectively. The results of experimentation indicated that absorption and distribution of SEM in Penaeus vannamei were fast and wide, but eifmination was slow.关键词
凡纳滨对虾/呋喃西林代谢物/氨基脲/药代动力学/残留/房室模型/统计距原理Key words
Penaeus vannamei/ metabolite of nitrofurazone/ semicarbazide/ pharmacokinetics/ residues/ compartmental/ statistical moment theory引用本文复制引用
王明兴,吴晓萍,廖艳,洪鹏志,陈华健,陈发武..呋喃西林代谢物在凡纳滨对虾体内代谢及残留[J].食品与机械,2013,29(1):76-80,5.基金项目
广东省教育部产学研结合项目(编号:2011B090400154) （编号:2011B090400154）
湛江市科技局重点专项(编号:湛财工[2010]180号) （编号:湛财工[2010]180号）
