沈阳农业大学学报2012，Vol.43Issue(4)：502-504,3.
大环内酯类药物对化脓隐秘杆菌防突变浓度的研究
Mutant Prevention Concentrations of Macrolides Antibiotics aganist Arcanobacterium Pyogenes
摘要
Abstract
The mutant prevention concentrations (MPC) of five macrolides antibiotics against A. pyogenes were measured in this study. The MPCs and select index(SI) of Erythromycin, Azithromycin, Tylosin, Acetylspiramycin and Timicosin against A. pyogenes were tested by the agar dilution method. The results were as following: the MPCs of Erythromycin, Azithromycin, Tylosin, Acetylspiramycin and Timicosin against A. pyogenes were 1.02μg·mL-1, 0.64μg·mL-1,0.2μg·mL-1, 0.8 μg·mL-1 and 1.02μg·mL-1, respectively; while the SIs were 25.5, 16, 10, 16 and 20.4, respectively. These results showed that the MPC and SI of Tylosin were the lowest among these antibiotics, which suggested that Tylosin would be the most effective way in curing the infection caused by A. pyogenes.关键词
防突变浓度/选择指数/大环内酯类/化脓隐秘杆菌Key words
mutant prevention concentrations/ select index/ macrolides antibiotics/ Arcanobacteriun pyogenes分类
农业科技引用本文复制引用
李杰,王巍,于立辉,刘耀川,王建民,张德显,刘明春..大环内酯类药物对化脓隐秘杆菌防突变浓度的研究[J].沈阳农业大学学报,2012,43(4):502-504,3.基金项目
国家自然科学基金项目(30972214) （30972214）
沈阳农业大学青年基金项目(20081020) （20081020）
