CT理论与应用研究2012，Vol.21Issue(4)：761-768,8.
冠脉CTA的主动脉处药物-时间曲线的生理药代动力学模型预测
Prediction of Aortic Contrast-enhancement Curves in Coronary CTA Using Physiologically Based Pharmacokinetic Model
原媛 1赵丽琴 1贺文1
作者信息
- 1. 首都医科大学附属北京友谊医院放射科,北京100050
- 折叠
摘要
Abstract
Objective:Our study focus on evaluating the accuracy of physiologically based pharmacokinetic (PBPK) model in simulation of enhancement at coronary CT angiography (CTA) Examination. Method and materials:80 patients (44 male, 36 female from 32 to 89 years old) underwent coronary CT angiography scan. A simulation software program was developed based on a pharmacokinetic model. For each patient, model parameters were adjusted according to patient age, sex, height, weight, scanning protocol, and contrast media administration protocol such as medium concentration and injection rate. Results:The simulated and actual CTA enhancement curves closely agreed in maximum enhancement and the average error is about 9.447±9.530%. 2 cases were excluded as invalid data. The simulated maximum enhancements of 59 cases were greater than their actual maximum enhancement and the average error was 7.86%. Meanwhile, 19 cases of simulation data were less than their actual data with the average error of 1.58%. The skewness of the whole data was α =-0.131. Conclusion:Our preliminary study suggests that PBPK model may predict the enhancement at coronary CTA with acceptable accuracy. Computer based PBPK model may be used in optimizing the coronary CTA scan protocol.关键词
生理药代动力学模型/冠脉CTA/造影剂Key words
physiologically based pharmacokinetic model/coronary CTA/contrast medium分类
医药卫生引用本文复制引用
原媛,赵丽琴,贺文..冠脉CTA的主动脉处药物-时间曲线的生理药代动力学模型预测[J].CT理论与应用研究,2012,21(4):761-768,8.
