食品科学2012，Vol.33Issue(23)：270-273,4.
鼠李糖乳杆菌B10通过抗氧化途径改善酒精性肝损伤的研究
Lactobacillus rhamnosus B10 Treatment Ameliorates Ethanol-induced Mouse Liver Injury by Antioxidant Pathways
摘要
Abstract
This study examined whether Lactobacillus rhamnosus B10 treatment can ameliorate ethanol-induced liver injury by antioxidant pathways in a mouse model of alcoholic steatohepatitis.Mice were randomly divided into control group,ethanol treatment group and L.rhamnosus B10 treatment group.After treatment for 8 weeks,blood samples were collected from the inferior vena cava of mice for the determination of serum ALT,LPS,MDA and SOD levels and mouse livers were observed for histopathological features and oxidative injury and analyzed for the contents of FFA(free fatty acids),TG and cholesterol.L.rhamnosus B10 treatment significantly relieved alcohol-induced fatty degeneration and oxidative injury in mice(P0.05),lowered the increase in the levels of serum ALT,LPS and MDA(P0.05),increased SOD activity(P0.05),and inhibited the increase in the levels of liver FFA,TG and cholesterol(P0.05).These findings suggest that L.rhamnosus B10 treatment can ameliorate alcohol-induced liver injury by antioxidant pathways in mice.关键词
鼠李糖乳杆菌B10/抗氧化/酒精性肝损伤Key words
Lactobacillus rhamnosus B10/antioxidant/alcohol-induced liver injury分类
医药卫生引用本文复制引用
王玉华,高晶,张静,胡耀辉..鼠李糖乳杆菌B10通过抗氧化途径改善酒精性肝损伤的研究[J].食品科学,2012,33(23):270-273,4.基金项目
国家自然科学基金青年科学基金项目 （）
长春市科技计划项目 （）
