食品科学2012，Vol.33Issue(23)：287-290,4.
口服透明质酸对小鼠佐剂性关节炎的作用
Therapeutic Effect of Oral Administration of Hyaluronic Acid on Adjuvant Arthritis in Mice
摘要
Abstract
Objective: To examine the therapeutic effect of oral administration of hyaluronic acid(HA) on adjuvant arthritis(AA) in mice.Methods: Forty 6-weeks-old healthy mice were randomly divided into 4 groups: normal,model,HA and diclofenac groups.AA mouse models were created by injection of Fluoride’s complete adjuvant(FCA) into the right hind paw.After 4 successive weeks of oral HA administration,mouse body weight and footpad thickness were measured and knee swelling was observed and scored.In addition,serum levels of interleukin-1(IL-1) and HA were assayed.Results: Oral HA administration resulted in a significant reduction in mouse footpad thickness and arthritis index and serum levels of IL-1 and HA and showed no significant differences in various indicators compared with diclofenac.Conclusions: Oral HA administration is effective at alleviating knee swelling,lowering serum interleukin-1 level and enhancing physical activities in AA mice and thus has a powerful therapeutic effect on adjuvant arthritis.关键词
口服透明质酸/动物模型/佐剂性关节炎Key words
oral administration of hyaluronic acid/animal model/adjuvant arthritis分类
轻工纺织引用本文复制引用
陈洁,增田泰伸,臼田美香,木村守,徐文斌,郑潮鹏,洪怡蓝,任晓静,奚印慈..口服透明质酸对小鼠佐剂性关节炎的作用[J].食品科学,2012,33(23):287-290,4.基金项目
上海海洋大学-日本丘比株式会社合作研究基金项目 （）
