食品科学2012，Vol.33Issue(23)：323-326,4.
姬菇多糖对酒精所致小鼠急性肝损伤的保护作用
Protective Effect of Polysaccharides from Pleurotus cornucopiae against Alcohol-Induced Acute Liver Injury in Mice
摘要
Abstract
The present study investigated the protective effect of polysaccharides in hot water extract from Pleurotus cornucopiae(PCNP) on alcohol-induced acute liver injury in mice.Mice were randomly divided into blank control,alcohol-induced liver injury model,positive control and PCNP treatment(at doses of 100,200 mg/(kg.d) and 400 mg/(kg.d) groups.After 30 consecutive days of intragastric administration,all the mice except for blank control group were given by gavage 50% alcohol at a dose of 12 mL/kg to induce acute liver injury.At 12 h after alcohol administration,all the mice in each group were killed by cervical dislocation and blood and liver were collected for the measurement of antioxidant indicators and pathological observation of liver tissue.Compared with the model group,PCNP administration resulted in a decrease in MDA content in the liver and the activities of AST,ALT in the serum,and an increase in the activities of SOD and CAT and GSH content in the liver of mice.In conclusion,PCNP can obviously improve pathological liver injury and protect against acute alcohol-induced liver injury in mice.关键词
姬菇多糖/急性肝损伤/抗氧化/血清/酒精Key words
Pleurotus cornucopiae polysaccharides/acute liver injury/antioxidant status/serum/alcohol分类
轻工纺织引用本文复制引用
周斌,陶明煊,程光宇,郭永月..姬菇多糖对酒精所致小鼠急性肝损伤的保护作用[J].食品科学,2012,33(23):323-326,4.基金项目
江苏省高校自然科学基础研究项目 （）
江苏省普通高校研究生科研创新计划项目 （）
