食品工业科技2013，Vol.34Issue(8)：86-87,101,3.
液相色谱-串联质谱法测定牛奶中万古霉素和去甲万古霉素残留
Simultaneous determination of vancomycin and norvancomycin in milk by liquid chromatography-tandem mass spectrometry
摘要
Abstract
A simple,rapid and specific analytical methods for the determination of vancomycin and norvancomycin in milk had been developed based on liquid chromatography tandem mass spectrometry in a multiple reaction monitoring mode. Milk samples were extracted with 0.1% trifluoroacetic acid in water. Antibiotics in the extract were separated on a ZORBAX SB-C18 column using a gradient elution program of 0.1% formic acid aqueous solution and acetonitrile. Limits of detection for vancomycin and norvancomycin were 5μg/kg. Mean recoveries were 72.5%~87.2%,and the relative standard deviation(RSD) was less than 10%.关键词
牛奶/万古霉素/去甲万古霉素/液相色谱-串联质谱Key words
milk/vancomycin/norvancomycin/liquid chromatography-tandem mass spectrometry分类
轻工纺织引用本文复制引用
郭启雷,史海良,杨红梅,王浩,刘艳琴..液相色谱-串联质谱法测定牛奶中万古霉素和去甲万古霉素残留[J].食品工业科技,2013,34(8):86-87,101,3.基金项目
国家质检总局科技计划项目(2011QK047). （2011QK047）
