郑州轻工业学院学报（自然科学版）2013，Vol.28Issue(1)：25-29,5.DOI:10.3969/j.issn.2095-476X.2013.01.006
6-羟基烟碱与烟碱的安全性比较研究
Study on the safety of 6-hydroxynicotine compared with nicotine
摘要
Abstract
The safety of 6-hydroxynicotine and nicotine was compared through toxicology test. The acute tox-icity and accumulative test was carried out on SPF mice (each of 30 ～ 35 g). After 35 d intragastrically each of 1.00 mg,0.75 mg,0.5 mg,0. 25 mg of nicotine and 6-hydroxynicotine (about receive the amount of a man pumping 20 cigarettes a day 8,6,4,2 times ), the organ coefficient of heart, liver, spleen, lung and kidney were calculated and bloodindicators of ALT, AST,TG were determined, the pathological examination was also done using liver, lung and kidney tissue. The results showed that 6-hydroxynicotine compared to nicotine significantly reduced in toxicity(P <0.05) ,low doses of nicotine does not cause organ lesions in mice.关键词
6-羟基烟碱/烟碱/安全性/毒理学试验Key words
6-hydroxynicotine/nicotine/safety/toxicology test分类
轻工纺织引用本文复制引用
马林,寇霄腾,帖金鑫,张文龙,张锐..6-羟基烟碱与烟碱的安全性比较研究[J].郑州轻工业学院学报（自然科学版）,2013,28(1):25-29,5.基金项目
国家自然科学基金资助项目(20976169) （20976169）
