茶叶科学Issue(3)：230-238,9.
六堡茶对胰岛素抵抗3T3-L1脂肪细胞糖脂代谢的影响
Effect of Liupao Tea on Glucose and Lipid Metabolism in Palmitate-induced Insulin Resistance 3T3-L1 Adipocytes
摘要
Abstract
To investigate the effect of Liupao tea on glucose and lipid metabolism in palmitate-induced insulin resistance 3T3-L1 adipocytes. Glucose intake decreased and insulin resistance was induced in 3T3-L1 adipocytes after incubation in 1mmol/L palmitate for 24 hours. Compared with the model group, the concentrations of glucose and NEFA decreased along with the increase of Liupao tea concentrations in medium. The mRNA expression of key enzyme for glycolysis of glucose (Hexokinase, 6-phosphofructokinase-1, and pyruvatekinase) and the Lipid-Metabolism-Related Enzymes (Sn-glycerol-3-phosphate acyltransferase) significantly increased in the Liupao tea groups comparing with model sample. Meanwhile the glucose transporter 4 mRNA expression was also increased and the acetyl-CoA carboxylase, protein tyrosine phosphatase 1B mRNA expression was decreased. Low doses of Liupao tea reduced carnitine palmitoyl transferase I mRNA expression while high doses significantly raised it. Research proved that Liupao tea were able to increase glucose uptake and activate the glucolipid metabolic pathways.Liupao tea showed the effect of improving insulin resistance induced by palmitate in 3T3 -L1 adipocytes.关键词
六堡茶/糖脂代谢/胰岛素抵抗/3T3-L1脂肪细胞Key words
Liupao tea/glucolipid metabolism/insulin resistance/3T3-L1 adipocytes分类
轻工纺织引用本文复制引用
滕翠琴,刘仲华,龚受基,彭雨轩,马蕊..六堡茶对胰岛素抵抗3T3-L1脂肪细胞糖脂代谢的影响[J].茶叶科学,2014,(3):230-238,9.基金项目
国家茶叶产业技术体系研究项目（CARS-23-10B）、国家自然科学基金项目（31100502）资助 （）
