摘要
Abstract
The study aims to investigate potential protection and mechanism of epigallocatechin gallate(EGCG) on kidney ischemia reperfusion injury. The results showed that EGCG treatment improved renal dysfuction, pathlogical change of kidney tissues, and reduced the expression of Wnt3a, β-catenin, MDA, IL-6, IFN-γ and TNF-α, but increased the levels of CAT, GPX and SOD, suggesting that EGCG can protect the kidney from ischemia-reperfusion injury in rats which is associated with suppressing the activation of Wnt/β-catenin/p53 signaling pathway and inhibiting inflammation and oxidative stress.关键词
表没食子儿茶素没食子酸酯/肾缺血再灌注损伤/炎症/氧化应激/Wnt/β-cateninKey words
EGCG/kidney ischemia reperfusion injury/inflammation/oxidative stress/Wnt/β-catenin分类
轻工纺织
