茶叶科学2016，Vol.36Issue(3)：237-244,8.
普洱茶对非酒精性脂肪肝大鼠肠道脂肪吸收及粘膜屏障的干预研究
Effect of Pu-erh Tea on Long Chain Fatty Acid Metabolism and Expression of Tight Junction Proteins in the Rat Model of Non-alcoholic Fatty Liver Disease
摘要
Abstract
In this study, the influence of Pu-erh tea on the absorption of long chain fatty acids in non-alcoholic fatty liver disease (NAFLD) rats was analyzed. Moreover, the possible interventional mechanism was also discussed. Thirty-six SD rats were randomly divided into three groups, normal group (NG), NAFLD group, and Pu-erh tea group (PTG), 12 rats for each group. All rats were killed after 8 weeks. Rat weight, liver index, serum lipid level, intestinal lipid absorption protein (CD36), tight junction proteins (Occludin, ZO-1), and TNF-α mRNA were measured. Compared with NAFLD group, rat weight and serum LDL-C in PTG were decreased by 16.12% and 42.59%, respectively. In addition, the expressions of CD36 and TNF-α mRNA in PTG were decreased, while occludin and ZO-1 mRNA expressions were increased. Our results suggest that Pu-erh tea can regulate the intestinal absorption of long chain fatty acids and the tight junction proteins in rats, and it is especially effective in prophylaxis against ‘the first attack’ in the early stage of NAFLD.关键词
普洱茶/非酒精性脂肪性肝病/脂质代谢/紧密连接Key words
Pu-erh tea/nonalcoholic fatty liver disease (NAFLD)/lipid metabolism/tight junction分类
轻工纺织引用本文复制引用
朱晟易,童钰铃,赵奕,吕海鹏,林智,沈国丽,孙婷,宋震亚..普洱茶对非酒精性脂肪肝大鼠肠道脂肪吸收及粘膜屏障的干预研究[J].茶叶科学,2016,36(3):237-244,8.基金项目
中医药重点研究计划 （）
