茶叶科学2016，Vol.36Issue(3)：250-260,11.
茯茶水提物对Ⅱ型糖尿病小鼠糖代谢紊乱的干预作用
Intervention Effects of Fuzhuan Brick Tea Water Extract on Glucose Metabolism Disorder in a Mouse Model of Type Ⅱ Diabetes Mellitus
摘要
Abstract
In this study, streptozotocin (STZ) combined with a high-fat and high-sugar diet was used to generate a mouse model of type 2 diabetes mellitus. The aim of this study was to investigate the hypoglycemic effects of Fuzhuan brick tea water extract (FTEs) on T2DM-Mice. Results showed that FTEs could obviously alleviate weight loss, polyuria, polydipsia, and polyphagia, reduce fasting plasma glucose, increase sugar tolerance, enhance insulin concentrations and insulin sensitivity and decrease insulin resistance in the diabetic mice. Moreover, RT-qPCR analysis showed that FTEs promoted glucose transport and liver lipid metabolism, and improved the glucose metabolism in the diabetic mice by increasing the expression of PPAR-α, GLUT2, and GLUT4. Therefore, it can be concluded that FTEs could significantly improve glucose metabolism disorder symptom of T2DM-Mice by a dose-dependent manner.关键词
茯茶水提物/Ⅱ型糖尿病/降糖/糖代谢Key words
Fuzhuan brick tea water extract/type 2 diabetes mellitus/hypoglycemic/glucose metabolism分类
轻工纺织引用本文复制引用
黄颂,刘仲华,黄建安,阳衡,李勤..茯茶水提物对Ⅱ型糖尿病小鼠糖代谢紊乱的干预作用[J].茶叶科学,2016,36(3):250-260,11.基金项目
国家自然科学基金（31471706）、湖南省自然科学基金（13JJ4067）、湖南省科技项目（15C0670）、湖南农业大学引进人才科学基金（13YJ13）。 （）
