食品科学2016，Vol.37Issue(13)：178-182,5.DOI:10.7506/spkx1002-6630-201613032
水解小麦蛋白肽对大鼠急性酒精性胃黏膜损伤的保护作用
Effect of Hydrolyzed Wheat Protein Peptide on Ethanol-Induced Acute Gastric Mucosal Damage in Rats
摘要
Abstract
Objective:The present work was aimed to examine the protective effect of hydrolyzed wheat protein peptide (HWP) in the model rats with acute gastric mucosal damage induced by ethanol. Methods: Hydrolyzed wheat protein peptide (167, 333 or 667 mg/(kg·d) (in body mass), cimetidine (65 mg/(kg·d)), or distilled water were administered daily by gavage for 30 days before the rats were treated with anhydrous ethanol (1 mL) and then euthanized after 1 h. Histological observation was performed to evaluate the antioxidant and anti-inflammatory activity of HWP as well as its impact on serum physiological and biochemical parameters and the expression of caspase-3 and epidermal growth factor receptor (EGFR). Results: Histological observation showed that ethanol-induced gastric mucosal damage was attenuated by hydrolyzed wheat protein peptide pretreatment. Hydrolyzed wheat protein peptide remarkably increased the superoxide dismutase (SOD) activity, epidermal growth factor (EGF) and prostaglandin E-2 (PGE2) levels in serum. Furthermore, it dramatically decreased malondialdehyde (MDA), platelet-activating factor (PAF) and interleukin-8 (IL-8) levels in serum. The expression level of caspase-3 in stomach was significantly decreased in hydrolyzed wheat protein peptide-treated rats when compared with the model group;however, the expression level of EGFR was markedly increased. Conclusion:Ethanol-induced gastric mucosal damage in rats can be protected against by hydrolyzed wheat protein peptide. The potential mechanism may be associated with the enhancement of antioxidant, anti-inflammatory and anti-apoptotic functions.关键词
水解小麦蛋白肽/胃黏膜损伤/酒精Key words
hydrolyzed wheat protein peptide/gastric mucosal damage/ethanol分类
医药卫生引用本文复制引用
杨贤,王少康,孙桂菊,王炎炎,王锋,夏惠,潘兴昌,朱航榉,谷瑞增,马永庆,唐华丽..水解小麦蛋白肽对大鼠急性酒精性胃黏膜损伤的保护作用[J].食品科学,2016,37(13):178-182,5.基金项目
国家高技术研究发展计划（863计划）项目（2013AA102205-02）；科技北京百名领军人才培养工程项目 （）
