食品科学2016，Vol.37Issue(13)：204-208,5.DOI:10.7506/spkx1002-6630-201613037
双歧杆菌BB12对便秘大鼠的通便作用及对胃肠激素的调节
Biifdobacterium BB12 Promotes Defecation and Regulates Gastrointestinal Hormones in Constipated Rats
摘要
Abstract
Objective: To investigate the effects of Bifidobacterium BB12 on promoting defecation and regulating gastrointestinal hormones in constipated rats. Methods: Totally 48 Wistar rats, half male and half female, were divided randomly into control group, positive control group, model group, Bifidobacterium BB12 low-, middle-, and high-dose groups. Rat models of loperamide hydrochloride-induced constipation were established and the rats from each group were treated with corresponding drugs. During the experiment, daily food intake, water intake, body weight, fecal number, fecal water content, gastrointestinal transit, and the contents of gastrin, motilin, substance P and somatostatin in serum were measured. Results: Fecal number, gastrointestinal transit, and the serum contents of motilin and substance P increased significantly, while water intake and somatostatin content decreased significantly in response to the administration of Biifdobacterium BB12. These effects were dependent on gender and dose. There was no signiifcant difference in food intake, body weight, fecal water content and serum gastrin. Conclusion: The laxative effect of Biifdobacterium BB12 is conifrmed and the underlying mechanism is related to regulating some gastrointestinal hormones.关键词
双歧杆菌/便秘/胃肠激素Key words
Biifdobacterium/constipation/gastrointestinal hormone分类
基础医学引用本文复制引用
田颖,戴倩倩,时明慧,孟婵芳,黄玉军,顾瑞霞..双歧杆菌BB12对便秘大鼠的通便作用及对胃肠激素的调节[J].食品科学,2016,37(13):204-208,5.基金项目
江苏省重点实验室开放课题 （）
