食品科学2016，Vol.37Issue(14)：193-197,5.DOI:10.7506/spkx1002-6630-201614035
聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律
Migration Pattern of Trimethyltin from PVC Food Packaging Materials to Food Simulants
摘要
Abstract
Objective:To develop an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for determining trimethyltin (TMT) in polyvinyl chloride (PVC) food packaging materials and four food simulants and to further study the migration pattern of TMT from the packaging materials to the food simulants. Methods: TMT was extracted from PVC food packaging materials with ethyl acetate. After purification and enrichment with OASIS MCX C18 cartridge, the eluate containing food simulants was evaporated to dryness with nitrogen in water bath, re-dissolved with the mobile phase, vortexed and filtered through a 0.22 μm membrane. The filtrate was detected by UPLC-MS-MS using positive ion electrospray ionization under multiple reaction monitoring (MRM) mode with a UPLC C18 column as separation column, and quantified by an external standard method. At different temperatures, PVC food packaging materials were soaked in four food simulants, namely, water, 10%ethanol solution, 3 g/100 mL acetic acid solution and n-hexane, respectively. At certain time points, the soaking solution was analyzed by UPLC-MS/MS. Results:The standard calibration curve of TMT was linear in the range of 0.1–100.0μg/L with a correlation coefficient of 0.999 8. The recoveries at three spiked levels (1.0, 10.0 and 50.0μg/L) ranged from 90.6%to 97.3%, with relative standard derivations (RSDs) lower than 6.9%. TMT was detected in the range of 0.19–1.65, 0.19–9.89, 0.11–9.96 and 0.15–3.54μg/L in water, 10%ethanol solution 3 g/100 mL acetic acid solution and n-hexane, respectively. Conclusion:The solid phase extraction-UPLC-MS/MS method is simple, reliable, accurate,and applicable to determinate TMT in food simulants. TMT in PVC food packaging materials easily migrates to 10% ethanol solution and 3 g/100 mL acetic acid solution. These results showed that TMT migration has positive correlations with temperature and time, but the process was balanced after a certain period of time.关键词
超高效液相色谱-串联质谱/三甲基锡/食品模拟物/聚氯乙烯/食品包装材料Key words
ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)/trimethyltin/food simulant/polyvinyl chloride (PVC)/food packaging materials分类
医药卫生引用本文复制引用
许欣欣,陈慧玲,毛丽莎,胡辛楠..聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律[J].食品科学,2016,37(14):193-197,5.基金项目
深圳市卫生计生系统科研项目 （）
