茶叶科学2016，Vol.36Issue(4)：347-353,7.
儿茶素单体对小鼠急性高尿酸血症的作用
Effects of Catechins on Acute Hyperuricemia in Mice
金红娜 1宋烨威 1崔卫波 2谢宏1
作者信息
- 1. 沈阳农业大学食品学院，辽宁 沈阳 110866
- 2. 苏州凯祥生物科技有限公司，江苏 苏州 215600
- 折叠
摘要
Abstract
The mouse model of acute hyperuricemia was established by using 300 mg·kg-1 oxonic acid potassium salt to evaluate the influence of catechins on serum uric acid. The xanthine oxidase (XOD) activity in serum and liver and the inhibitory effect of catechins on XOD in vitro was further studied. Results showed that with dosage of 600 mg·kg-1, EC, ECG and EGC reduced the serum uric acid level in vivo significantly by 23% (P<0.001), 35%(P<0.001) and 37% (P<0.001), respectively compared with the model group. ECG could reduce XOD activity in serum and liver approximately by 31% (P<0.01) and 32% (P<0.05). In vitro, ECG and EGCG could inhibit XOD activity. Therefore EC, ECG and EGC could reduce the level of uric acid of hyperuricemia mice. The mechanism of uric acid lowering effect of ECG might be associated with its inhibitory effect on XOD.关键词
儿茶素/高尿酸血症/黄嘌呤氧化酶Key words
catechins/hyperuricemia/xanthine oxidase分类
农业科技引用本文复制引用
金红娜,宋烨威,崔卫波,谢宏..儿茶素单体对小鼠急性高尿酸血症的作用[J].茶叶科学,2016,36(4):347-353,7.
