顶空气相色谱法测定单磷酸阿糖腺苷原料药中5种残留溶剂OA北大核心CSTPCD
Determination of Five Residual Solvents in Vidarabine Monophosphate by Headspace Gas Chromatography
目的：建立测定单磷酸阿糖腺苷原料药中乙醇、乙腈、二氯甲烷、乙酸乙酯、吡啶5种残留溶剂的方法。方法：采用顶空进样气相色谱法。色谱柱为Agilent DB-624毛细管柱，程序升温，进样口温度为200℃，检测器为氢火焰离子化检测器，检测温度为250℃，载气为氮气，流速为3 ml/min，进样方式为分流进样，分流比为1∶1，顶空平衡温度为100℃，平衡时间为45 min，进样量为1 ml。按外标法进行定量分析。结果：5种残留溶剂峰分别与相邻峰分离完全。…查看全部>>
OBJECTIVE:To establish a method for the determination of ethanol,acetonitrile,dichloromethane,ethyl acetate, pyridine in vidarabine monophosphate. METHODS:Headspace GC was performed on the column of Agilent DB-624,programmed temperature,inlet temperature was 200 ℃,the detector was flame ionization detector,detecting temperature was 250 ℃,nitrogen was carrier gas,flow rate was 3 ml/min,split ratio was 1∶1,the top bottles equilibrium temperature was 100 ℃,and …查看全部>>
焦旭雯;陈华;梁蔚阳
广东省药品检验所，广州 510180广东省药品检验所，广州 510180广东省药品检验所，广州 510180
医药卫生
单磷酸阿糖腺苷顶空气相色谱法残留溶剂检测
Vidarabine monophosphateHeadspace GCResidual solventDetermination
《中国药房》 2016 (24)
3408-3409,3410,3
广东省医学科学技术研究基金项目（No.A2015256）；广东省食品药品检验检测技术创新专项资金项目（No.2015ZX05）
评论