食品科学2016，Vol.37Issue(19)：222-226,5.DOI:10.7506/spkx1002-6630-201619037
白藜芦醇对大鼠代谢网络通量的影响
Effect of Resveratrol on Metabolic Network Flux in Rats
摘要
Abstract
A large number of studies have shown that lactic acid metabolism flux can be used to quantitatively describe the state of the body in the condition of normal life. When it is reduced, the body is in good shape; in contrast, when it is increased, the body is in the state of inflammation or detoxification. In recent years, a number of reports have demonstrated the prevention of diseases of modern civilization by resveratrol and it is evident that this effect is closely related to lactate metabolism flux. However, studies on its metabolism in the body have rarely been reported. In the present study, one control group and three resveratrol treatment groups at low, medium and high doses (2, 20 and 200 mg/kg), each consisting of 6 male rats were designed. After the rats were administered by gavage, a metabolic network model for metabolic flux analysis was established. The results showed that the body catabolism was reduced by administration of 2 mg/kg of resveratrol, but it was increased dose-dependently when the dose was over 20 mg/kg. Based on these results, resveratrol at 2 mg/kg could result in the lowest body catabolism, suggesting that it can help prevent and treat diseases of modern civilization. As it resulted in a significant increase in the body catabolism, resveratrol at 200 mg/kg could cause toxic side effects to the body. Therefore, resveratrol can play a role in protecting the body against diseases only in a certain dose range.关键词
白藜芦醇/代谢通量/大鼠Key words
resveratrol/metabolic flux/rat分类
轻工纺织引用本文复制引用
胥连杰,王会松,庞广昌..白藜芦醇对大鼠代谢网络通量的影响[J].食品科学,2016,37(19):222-226,5.基金项目
国家自然科学基金面上项目 （）
