经颅电刺激对阿尔兹海默病大鼠学习记忆能力和海马 CA1区磷酸化 tau 蛋白表达情况的影响OA北大核心CSTPCD
Influences of transcranial electrical stimulation onlearning and memory ability andphosphorylated tau protein ex-pression of hippocampal CA1 area in rats with Alzheimer’ s diseases
目的：探讨经颅电刺激对阿尔兹海默病（Alzeheimer’s disease，AD）大鼠学习记忆能力和海马CA1区磷酸化tau蛋白表达的影响。方法健康SD大鼠，随机分为：正常组、假手术组、模型组及经颅电刺激2 w、4 w、6 w组。采用大鼠侧脑室注射Aβ25-35凝聚态β-淀粉样肽，同时腹腔注射D-半乳糖的方法，建立AD动物模型。Morris水迷宫实验检测各组大鼠学习、记忆能力，HE染色，观察海马CA1区形态学结构，免疫组化测定海马CA1区磷酸化…查看全部>>
Objective To evaluate the influences of transcranial electrical stimulation onlearning and memory ability andphosphorylated tau protein expression of hippocampal CA 1 area in rats with Alzheimer ’ s diseases .Methods Healthy SD rats were randomly divided into:the normal group,the sham-operation group,the model group,and 2-week,4-week,and 6-week transcranial electrical stimulation groups .Rats were given Aβ25-35 condensed state β-amyloid peptide via lateral v…查看全部>>
刘玥;刘芳
贵州医科大学附属医院神经内科，贵州 贵阳550004贵州医科大学附属医院神经内科，贵州 贵阳550004
临床医学
阿尔茨海默病经颅电刺激海马CA1 区学习记忆磷酸化tau蛋白
Alzheimer ’ s diseaseTranscranial electrical stimulationHippocampal CA 1 areaLearning and memoryPhosphorylated tau protein
《中风与神经疾病杂志》 2016 (12)
1104-1106,3
贵州省科技技术基金［No．黔科合J字（2011）2236号］
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