CT理论与应用研究2017，Vol.26Issue(1)：85-90,6.DOI:10.15953/j.1004-4140.2017.26.01.11
磁共振弥散张量成像在早期帕金森病诊断中的应用研究
Application of Diffusion Tensor Imaging in the Early Diagnosis of Parkinson's Disease
摘要
Abstract
Objective: To explore the diagnostic value of diffusion tensor imaging in early Parkinson disease (PD). Methods: There were 18 patients with primary early PD and 18 volunteers as control group. Conventional MR sequences and DTI images were examined. The fractional anisotropy (FA) value and apparent diffusion coefficient (ADC) value of the bilateral thalamus, caudate nucleus, substantia nigra, putamen and globus pallidus were evaluated. Results: The FA value of thalamus, caudate nucleus and substantia nigra in PD group was significantly lower than that in the control group (P < 0.05). The FA value of bilateral putamen and globus pallidus was no significant difference between the two groups (P > 0.05). No significant difference was found in ADC value between the two groups. Conclusion: The changes of FA value in the thalamus, caudate nucleus and substantia nigra can help to recognize and detect PD. This study suggests that DTI may provide valuable clue for early diagnosis of PD.关键词
帕金森病/弥散张量成像/各向异性Key words
Parkinson disease/diffusion tensor imaging/anisotropy分类
医药卫生引用本文复制引用
杨涛,张春艳,程敬亮,刘康永,范晓军,王伟,张叶,刘飞..磁共振弥散张量成像在早期帕金森病诊断中的应用研究[J].CT理论与应用研究,2017,26(1):85-90,6.基金项目
上海市卫计委项目；上海健康医学院种子基金重点项目（HMSF-16-21-027）。 （）
