食品工业科技2016，Vol.37Issue(11)：350-354,361,6.DOI:10.13386/j.issn1002-0306.2016.11.064
胰脂肪酶特异性卵黄抗体对胰脂肪酶活性的抑制作用研究
Inhibitory effect of the specific chicken egg yolk antibody on pancreatic lipase in vitro
摘要
Abstract
Obesity is one of the most serious risks for human health,and the development of pancreatic lipase inhibitors is attracting increasing attention as a useful approach for the prevention and treatment of obesity.Egg yolk antibody(L-IgY) against pancreatic lipase was raised by the immunization of chicken successfully for the first time.Results showed that the specific IgY was a non-competitive pattern inhibitor with the IC50value calculated as 168.62 iμg/mL.The IgY would be degraded in the gastric digestion in 10 min,but was stable in simulated intestinal conditions activity decreased about 20％ in 2 h,which suggested the IgY was a safe,novel and promising candidate for the prevention and treatment of obesity.关键词
卵黄抗体/胰脂肪酶/抑制/肥胖Key words
egg yolk antibody/pancreatic lipase/inhibition/obesity分类
轻工纺织引用本文复制引用
刘帅,曹立民,林洪,隋建新..胰脂肪酶特异性卵黄抗体对胰脂肪酶活性的抑制作用研究[J].食品工业科技,2016,37(11):350-354,361,6.基金项目
中央高校基本科研业务费专项(201413061). （201413061）
