食品工业科技2017，Vol.38Issue(5)：49-53,59,6.DOI:10.13386/j.issn1002-0306.2017.05.001
蛹虫草基质多糖纳米硒复合物的制备研究
Study on the preparation of Cordyceps militaris polysaccharide/Nano-Selenium complex
摘要
Abstract
Polysaccharides was used as soft template to prepare polysaccharide/Nano-Selenium complexes,which had high biological activity and low toxicity.The preparation procedure of Nano-Se/Cordyceps militaris stroma polysaccharides complexes was investigated by single-factor experiment and orthogonal experimental design,and the water-soluble polysaccharide which was exacted from the abandoned cordyceps militaris culture medium was used as the raw material.The results showed that the optimal reaction conditionswere as follows:the polysaccharide concentration was 10 mg/mL,selenite concentration was 0.4 mol/L,the mixing time was 4 hours,the preparation conditions of dropping was 1.5 r/min.Under the optimal condiction,the ideal morphology,ideal particle size,stable and good nano selenium/Cordyceps militaris stroma polysaccharide complex particles (CMSP-SeNPs) could be successfully prepared.The antitumor experiment results showed that CMSP-SeNPs could inhibit the proliferation of Caco-2 cells,which presented a certain dose-response relationship.关键词
蛹虫草/多糖/硒/纳米/抗肿瘤Key words
Cordyceps militaris/polysaccharide/Selenium/Nano/antitumor分类
轻工纺织引用本文复制引用
武童,汪振炯,吴雨龙,江海涛,周峰,王仁雷,华春,池玥兰..蛹虫草基质多糖纳米硒复合物的制备研究[J].食品工业科技,2017,38(5):49-53,59,6.基金项目
国家自然科学基金项目(21376112,31471699) （21376112,31471699）
国家高技术研究发展计划项目(2012AA021701) （2012AA021701）
江苏省自然科学基金(BK20131344,BK20141081) （BK20131344,BK20141081）
2015年江苏省大学生实践创新训练计划项目(201511460007Z) （201511460007Z）
南京晓庄学院校科研项目(2012NXY08). （2012NXY08）
