食品工业科技2017，Vol.38Issue(6)：345-349,5.DOI:10.13386/j.issn1002-0306.2017.06.057
红松松塔多酚对S180荷瘤小鼠抗肿瘤及免疫活性
Antitumor and immunomodulation activities of polyphenols from pinecone of Pinus koraiensis in cancer-bearing S180 mice
伊娟娟 1王振宇 1周丽萍 2王化 2李景彤 1曲航1
作者信息
- 1. 哈尔滨工业大学化工学院,黑龙江哈尔滨150090
- 2. 黑龙江省科学院自然与生态研究所,黑龙江哈尔滨150040
- 折叠
摘要
Abstract
Objective:The aim of this study was to investigate the antitumor and immunoregulatory activities of the 40％ ethanol eluent of polyphenols from pinecone of Pinns koraiensis (PPP-40) on S180 mice.Methods:Firstly,S180 solid tumor-bearing mice were given PPP-40 by oral for 10 days.Then,the tumor inhibition rate,cell cycle of tumor cells,spleen index and spleen lymphocytes proliferation ability were analyzed.Results:Pretreatment with PPP-40 (150 mg/kg) could significantly inhibit of tumor growth (Inhibition rate:48.29％,p ＜ 0.01),promote tumor cells cycle arrest at G0/G1 and G2/M,enhance spleen index (3.29 ± 0.26,p ＜ 0.01) and accelerated the proliferation of splenocytes (p ＜ 0.01).Conclusion:These results suggested that PPP -40 was a natural antitumor agent and possesses strong antitumor effect in S180 mice(p ＜ 0.01).The antitumor effect may be related to the arrest of tumor cell cycle and the improvement of immunomodulatory activity.关键词
红松松塔多酚/S180小鼠模型/抗肿瘤/免疫活性Key words
polyphenols of Pinus koraiensis pinecone/S180 solid tumor/antitumor activity/immunomodulation activity分类
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伊娟娟,王振宇,周丽萍,王化,李景彤,曲航..红松松塔多酚对S180荷瘤小鼠抗肿瘤及免疫活性[J].食品工业科技,2017,38(6):345-349,5.
