食品科学2017，Vol.38Issue(6)：242-247,6.DOI:10.7506/spkx1002-6630-201706038
响应面试验优化猴头菌素-PLGA微球制备工艺及其体外释药性能
Optimized Preparation and in Vitro Release Properties of Erinacines-PLGA Microspheres by Response Surface Methodology
摘要
Abstract
Purpose:To prepare slow-release erinacines microspheres with poly (lactic-co-glycolic acid) (PLGA) as carry using the emulsification solvent evaporation method and to investigate their release characteristics in vitro.Methods:The one-factor-at-a-time method was adopted to examine the factors affecting encapsulation efficiency,and their levels were optimized using response surface methodology.Results:The optimum preparation conditions were obtained as follows:erinacines to PLGA ratio,1∶1.64 (g/g);concentration of PLGA in dichloromethane,15％;and stirring speed,1 200 r/rain.The obtained microspheres were complete and smooth with an encapsulation efficiency of 99.66％ and a cumulative release rate in vitro of 84.30％ in 384 h.Conclusion:The emulsification solvent evaporation method has been successfully applied to prepare erinacines microspheres with high entrapment efficiency and good sustained release performance.关键词
猴头菌素/聚乳酸-羟基乙酸共聚物(PLGA)/微球/体外释药Key words
erinacines/poly (lactic-co-glycolic acid) (PLGA)/microspheres/drug release in vitro分类
轻工纺织引用本文复制引用
何晋浙,姚丽娜,孙培龙..响应面试验优化猴头菌素-PLGA微球制备工艺及其体外释药性能[J].食品科学,2017,38(6):242-247,6.基金项目
国家高技术研究发展计划(863计划)项目(2014AA022205) （863计划）
