中国食物与营养2017，Vol.23Issue(2)：15-18,4.
葡萄籽原花青素缓解硝基苯酚诱导的免疫毒性
Grape Seed Proanthocyanidin Attenuates Immunotoxicity Induced by Nitrophenol
摘要
Abstract
3-methyl-4-nitrophenol (PNMC),as a kind of important component of vehicle emissions,has been shown to confer toxicity in splenocytes.Proanthocyanidin,as a dietary polyphenols,has been shown to confer inhibitory activity against a variety of toxins,and grape seed is rich in proanthocyanidins.The effects of grape seed proanthocyanidin on immunotoxicity induced by PNMC in murine splenic lymphocytes were investigated by Cell Viability Assay and ELISA,and the results showed that grape seed proanthocyanidin significantly enhanced proliferation of splenocytes exposed to PNMC,as well as the production of T cell-related cytokines and granzymes including interleukin-2,interleukin-4,and granzyme-B in the cells exposed to PNMC.These effects were associated with a decrease in oxidative stress,as evidenced by changes in OH ·,SOD,GSH-Px,and MDA levels.关键词
葡萄籽原花青素/3-甲基-4-硝基苯酚/缓解免疫毒性/脾淋巴细胞Key words
grape seed proanthocyanidin/3-methyl-4-nitropheno (PNMC)/attenuates immunotoxicity/splenic lymphocyte引用本文复制引用
万一方,叶思言,段淑琪,杜声杰,阮馨慰,许美玉..葡萄籽原花青素缓解硝基苯酚诱导的免疫毒性[J].中国食物与营养,2017,23(2):15-18,4.基金项目
北京林业大学“北京市大学生科学研究与创业行动计划”(项目编号:S201510022036) （项目编号:S201510022036）
北京市自然科学基金(项目编号:8142029). （项目编号:8142029）
