现代食品科技2017，Vol.33Issue(3)：29-34,6.DOI:10.13982/j.mfst.1673-9078.2017.3.005
黑果枸杞花青素对Aβ42致痴呆模型大鼠记忆力及抗氧化活性研究
Memory Enhancing and Antioxidant Activities of Lycium ruthenicum Murray Anthocyanin Extracts in an Aβ42-Induced Rat Model of Dementia
摘要
Abstract
Amyloid beta-protein 1-42 (Aβ42) was injected bilaterally into the hippocampal CA1 area of rats to produce an animal model of Alzheimer's disease (AD),and animal behavior was assessed using the passive-avoidance test in a shuttle box.The activities of total superoxide dismutase (T-SOD) and catalase (CAT),and the contents of glutathione (GSH),malondialdehyde (MDA),and protein carbonyl (PC) in serum and brain tissues were used as evaluation indicators to investigate the effect of Lycium ruthenicum Murray anthocyanin extracts on the in vivo antioxidant activity and memory function of AD model rats.The results showed that the memory capacity of the model group was significantly decreased,while the memory impairment of rats administered Lycium ruthenicum Murray anthocyanin extracts was alleviated.Additionally,the activities of T-SOD and CAT,and the content of GSH in serum and brain tissues were significantly enhanced,whereas MDA and PC contents were decreased in the group that received 80 mg/kg Lycium ruthenicum Murray anthocyanin extracts.Thus,Lycium ruthenicum Murray anthocyanin extracts could enhance memory capacity and antioxidant activities of AD model rats,and had a potential preventive effect against AD.关键词
黑果枸杞花青素/Aβ42/阿尔茨海默症/抗氧化/记忆力Key words
Lycium ruthenicum murray anthocyanin extracts/amyloid beta-protein 1-42/Alzheimer's disease/antioxidant/memory引用本文复制引用
武雪玲,李筱筱,贾世亮,高兆兰,鲁政,戴雪伶,孙雅煊..黑果枸杞花青素对Aβ42致痴呆模型大鼠记忆力及抗氧化活性研究[J].现代食品科技,2017,33(3):29-34,6.基金项目
北京市教委面上顶目(SQKM201411417014) （SQKM201411417014）
北京联合大学校级科研项目(ZK70201402) （ZK70201402）
