现代食品科技2017，Vol.33Issue(3)：40-46,7.DOI:10.13982/j.mfst.1673-9078.2017.3.007
坛紫菜多糖对两种突变剂诱导的大蒜根尖细胞损伤的保护作用
Porphyran Reduces Cytotoxicity Induced by Two Carcinogens in Allium sativum Root Cells
摘要
Abstract
Studies have shown that porphyran extracted from the red algae Porphyra haitanesis has a potential antioxidant activity.The effect of porphyran and its sulfate derivatives on cyclophosphamide (CP)-and mitomycin C (MMC)-induced changes in micronucleus rate,mitotic index,chromosome aberration rate,and lipid peroxidation in Allium sativum root cells was investigated.The results indicated that the polysaccharide significantly inhibited the micronucleus rate and chromosomal aberration rate,and significantly enhanced the mitotic index in a dose dependent manner.The polysaccharide exhibited the highest inhibitory and enhancing effects at 100 mg/L concentration.Additionally,the sulfate derivative exhibited superior resistance towards lipid peroxidation in cells compared to that exhibited by the unmodified polysaccharide.The analysis reveals that the anti-carcinogenic effect of porphyran has a definite relationship with anti-lipid peroxidation activity,and shows that the sulfate group has an indirect effect on anti-carcinogenic activity.The results showed that porphyran has an anti-carcinogenic potential.关键词
坛紫菜多糖/大蒜根尖/环磷酰胺/丝裂霉素-CKey words
porphyran/Allium sativum root/cyclophosphamide/mitomycin C引用本文复制引用
张忠山,王晓梅,刘重斌..坛紫菜多糖对两种突变剂诱导的大蒜根尖细胞损伤的保护作用[J].现代食品科技,2017,33(3):40-46,7.基金项目
浙江自然科学基金资助项目(LQ14C200003,LQ16D060005) （LQ14C200003,LQ16D060005）
浙江省近岸水域生物资源开发与保护重点实验室开放基金项目(J2015003) （J2015003）
