现代食品科技2017，Vol.33Issue(4)：306-314,9.DOI:10.13982/j.mfst.1673-9078.2017.4.047
益生菌抑制N-亚硝基化合物诱发结肠癌的研究进展
Research Progress on the Inhibitory Effects of Probiotics on N-nitroso Compound-induced Colon Carcinoma
摘要
Abstract
Colon carcinoma,one of the most prevalent malignant tumors,is a serious threat to human health and life.The incidence of colon cancer is a result of the interaction of multiple factors,so there are many difficulties in the prevention and control of colon carcinoma.Currently,numerous drugs are used in the treatment of colon carcinoma,but they all have varying degrees of adverse effects.Therefore,researchers have been working on the development of new,targeted drugs for colon carcinoma without toxic effects.Previous studies have confirmed that fermented foods enriched with probiotic bacteria can decrease the incidence of cancer and have a certain protective effect against colon carcinoma development.Probiotic bacteria exhibited significant anticancer effects in in vitro experiments and also reduced the genotoxicity of carcinogens to colon tissue cells in in vivo animal experiments.N-nitroso compounds have been confirmed as carcinogenic substances that exist widely in processed meat products,and their excessive intake can increase the risk of colon carcinoma.Therefore,this article discusses the effect of probiotic bacteria on the suppression of colon carcinoma development induced by foodborne carcinogens (N-nitroso compounds).关键词
益生菌/结肠癌/致癌物/N-亚硝基化合物Key words
probiotic/colon carcinoma/carcinogen/N-nitroso compounds引用本文复制引用
王淑梅,张兰威,薛朝辉,李洪波,孙宇,迟治平..益生菌抑制N-亚硝基化合物诱发结肠癌的研究进展[J].现代食品科技,2017,33(4):306-314,9.基金项目
国家“十二五”科技863资助项目(2011AA100902) （2011AA100902）
国家自然科学基金资助项目(31271906/C200204) （31271906/C200204）
黑龙江省博士后基金资助项目(LBH-Z15018) （LBH-Z15018）
哈尔滨学院青年基金资助项目(HUDF2015-001) （HUDF2015-001）
