现代食品科技2017，Vol.33Issue(5)：1-6,13,7.DOI:10.13982/j.mfst.1673-9078.2017.5.001
辣椒抽提物对缓解小鼠食源性肥胖及调控基因表达的作用
Inhibitory Effects of Pepper Extract on High-fat Diet-induced Obesity and Gene Expression in Mice
摘要
Abstract
The aim of this study was to compare the effects of an ethanol extract of Erjingtiao pepper and purified capsaicin on high-fat diet-induced obesity in mice,and the study provided a theoretical basis for alleviation of high-fat diet-induced obesity by the pepper extract.C57BL/6 mice were subdivided into four groups:normal control group (n=ten),high-fat diet group (n=ten),pepper extract + high-fat diet group (n=ten),and purified capsaicin + high-fat diet group (n=ten).The results showed that compared with purified capsaicin,the pepper extract more effectively suppressed the body weight gain of the mice,decreased fat accumulation and adipocyte size,and reduced the levels of total cholesterol (TC) and triglycerides (TGs) in serum,liver,and feces.In the liver and adipose tissues,the expression levels of lipid degradation genes [proliferator-activated receptor α (PPARα),cholesterol 7 α-hydroxylase (CYP7A1),lipoprotein lipase (LPL),and carnitine palmitoyltransferase Iα (CPT1α)] were significantly decreased in the high-fat diet group,and were significantly increased in the pepper extract + high-fat diet group and purified capsaicin + high-fat diet group.The increased expression of these genes in the pepper extract + high-fat diet group was even higher than that in the purified capsaicin + high-fat diet group.Lipid synthesis-activating genes [proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα)] were upregulated in the high-fat diet group,pepper extract + high-fat diet group,and purified capsaicin + high-fat diet group,but the pepper extract + high-fat diet group showed the smallest increase.Therefore,both the pepper extract and capsaicin can alleviate obesity,but the pepper extract has a better effect.关键词
辣椒/减肥/基因/辣椒碱/抽提Key words
pepper/weight loss/gene/capsaicin/extract引用本文复制引用
丁城,梁言,田敏,胡梦阳,胡勇..辣椒抽提物对缓解小鼠食源性肥胖及调控基因表达的作用[J].现代食品科技,2017,33(5):1-6,13,7.基金项目
湖北省大学生创新创业训练计划项目(201410500019) （201410500019）
湖北省自然科学基金项目(2015CFB678) （2015CFB678）
湖北省教育厅科学技术研究计划青年人才项目(Q20151412) （Q20151412）
湖北工业大学博士启动基金项目(BSQD10036) （BSQD10036）
