现代食品科技2017，Vol.33Issue(5)：7-13,7.DOI:10.13982/j.mfst.1673-9078.2017.5.002
低聚果糖靶向调节肠道菌群缓解力竭运动导致的脂质代谢紊乱
Fructo-oligosaccharides Protect Mice against Exhaustive Exercise-induced Dyslipidemia by Modulating Gut Microbial Composition and Function
摘要
Abstract
To investigate the possible mechanism of fructo-oligosaccharides (FOS) in regulating lipid metabolism,male balb/c mice were randomly divided into three groups:control group (Control),exhaustive exercise group (Motion),and FOS intervention group (FOS).A forced exercise wheel-track treadmill was used in this study,and animals in both Motion and FOS groups were subjected to an exhaustive exercise protocol while the animals in the Control group were kept still.After sixteen days of treatments,the related serun lipid parameters were measured and fecal samples were collected to investigate gut microbiota changes by metagenome.The results showed that the serum total cholesterol content,LDL-C,and HDL-C increased sharply (p＜0.05),while the serum triglyceride content decreased significantly (p＜0.01).Therefore,exhaustive exercise could be an important factor in lipid metabolism disorders.Our data also showed that a 16 d FOS treatment resulted in a profound change in microbiome structure,which subsequently led to widespread shifts in the gut functional potential.Together,our findings suggest that FOS may protect mice against exhaustive exercise-induced dyslipidemia by modulating gut microbial composition,improving lipid metabolism within microbiota,and regulating enzymes activities involved in fatty acid oxidation and lipid synthesis.关键词
低聚果糖/力竭运动/脂质代谢紊乱/肠道菌群/宏基因组Key words
fructo-oligosaccharides/exhaustive exercise/dyslipidemia/gut microbiota/metagenome引用本文复制引用
张娜,李晶,宋佳,毛相朝,王玉明,王静凤,唐庆娟..低聚果糖靶向调节肠道菌群缓解力竭运动导致的脂质代谢紊乱[J].现代食品科技,2017,33(5):7-13,7.基金项目
国家自然科学基金项目(U1406402) （U1406402）
国家自然科学基金青年科学基金项目(30471225) （30471225）
