食品工业科技2017，Vol.38Issue(7)：141-144,150,5.DOI:10.13386/j.issn1002-0306.2017.07.019
高产洛伐他汀红曲霉(Monascus sp.UV-D-9)的发酵条件优化
Optimization of fermentation conditions on lovastatin yield by Monascus sp.UV-D-9
摘要
Abstract
The fermentation conditions of Monascus sp.UV-D-9,which was a high-yield mutant obtained by complex mutagenesis,were optimized by Response Surface Methodology (RSM)to further improve lovastatin yield.The optimum fermentation conditions were received as follows:the fermentation temperature(X1)was 30.4 ℃,the medium volume (X2)was 134 mL,the rotation speed (X3)was 187 r·min-1,fermentation time was 10 d and inoculation amount was 8％.The lovastatin yield of Monascus sp.UV-D-9 under the optimum conditions was (0.32 ± 0.014)mg·mL-1 (n =3),which was increased by 10.1％ in comparison with the original condition.关键词
洛伐他汀/红曲霉UV-D-9/响应曲面法/发酵条件/优化Key words
lovastatin/Monascus sp.UV-D-9./RSM/fermentation condition/optimization分类
轻工纺织引用本文复制引用
游玟娟,温拥军..高产洛伐他汀红曲霉(Monascus sp.UV-D-9)的发酵条件优化[J].食品工业科技,2017,38(7):141-144,150,5.基金项目
湖南省教育厅科学研究项目(15C0466). （15C0466）
