食品与机械2017，Vol.33Issue(4)：49-53,5.DOI:10.13652/j.issn.1003-5788.2017.04.010
木薯蚕蛹的急性毒性与遗传毒性
The acute toxicity and genotoxicity of Cassava Silkworm Pupa
摘要
Abstract
Objective:To study the acute toxicity and genotoxicity of silkworm pupa.Methods:The study was carried out by acute toxicity test and genotoxicity test.The genetic toxicity test was divided into micronucleus test in Vicia faba root tip cells,mouse bone marrow micronucleus test and mouse sperm abnormality test.Re sults:The maximum tolerated dose of the mouse to the silkworm chrysalis was greater than 16 g/kg · bw in acute toxicity test,which meant that this substance was non-toxic.In genetic test,compared with negative control,when the concentration of cassava silkworm chrysalis was above 250 mg/mL,the broad bean root tip micronudeus rate increased significantly (P＜0.01);when the dose is 5 g/kg · bw and 2.5 g/kg · bw,cassava silkworm chrysalis could significantly increase the male and female mice bone marrow micronucleus rate respectively (P＜ 0.05);in 5 g/kg · bw,cassava silkworm chrysalis could significantly increase the odds of male mice sperm aberration (P＜ 0.01).Conclusion:Under experimental condition,the acute toxicity of cassava silkworm pupa was not observed,but the genetic toxicity could be observed in high doses.关键词
木薯蚕蛹/急性毒性/遗传毒性Key words
cassava silkworm pupa/acute toxicity/genetic toxicity引用本文复制引用
李玲,龙悦,丁晓雯,黄先智..木薯蚕蛹的急性毒性与遗传毒性[J].食品与机械,2017,33(4):49-53,5.基金项目
国家现代农业(桑蚕)产业技术体系建设专项(编号:CARS-22-ZJ0503) （桑蚕）
