食品科学2017，Vol.38Issue(3)：201-205,5.DOI:10.7506/spkx1002-6630-201703033
马齿苋多糖POPⅡ和POPⅢ的抗肿瘤及提高免疫力作用
Antitumor and Immunoenhancing Effects of Polysaccharides POP Ⅱ and POP Ⅲ from Portulace oleracea L.
摘要
Abstract
The aim of the present study was to examine the antitumor and immunoenhancing effects of two polysaccharides (POP Ⅱ and POP Ⅲ) isolated and purified from Portulace oleracea L.in Lewis lung tumor-bearing mice.The mice subcutaneously implanted with Lewis lung tumor cells on their toes were intraperitoneally injected with each polysaccharide at doses of 100 and 50 mg/kg (body weight) for 10 days,respectively.Meanwhile,cyclophosphamide (CTX) was used as antitumor positive control,and Coriolus versicolor polysaccharopeptide was used as immunoenhancing positive control,and the same volume of normal saline was used as negative control.The results showed that the tumor growth inhibition rates of POP Ⅱ were 35.10％ and 41.01％,while those of POP Ⅲ were 36.91％ and 45.11％ at the low and high doses,respectively.Both treatment groups were significantly different from the negative control (P ＜ 0.05).Moreover,POP Ⅱ and POP Ⅲ exhibited a stimulating effect on the cytotoxicity of natural killer (NK) cells with a significant difference when compared with the negative control (P ＜ 0.05).Meanwhile,both of them could accelerate the conversion of lymphocytes with a stimulation index of 1.27-1.33,showing significant differences when compared with the negative control (P ＜ 0.05).In a word,POP Ⅱ and POP Ⅲ can improve thymus index and spleen index in normal mice and thus play a significant role in antitumor and immunoenhancing functions.关键词
马齿苋/多糖/抗肿瘤/提高免疫力Key words
Portulace oleracea L./polysaccharide/antitumor/immunoenhancing分类
医药卫生引用本文复制引用
牛广财,李世燕,朱丹,魏文毅,王赢..马齿苋多糖POPⅡ和POPⅢ的抗肿瘤及提高免疫力作用[J].食品科学,2017,38(3):201-205,5.基金项目
黑龙江八一农垦大学出国留学基金资助项目(BYND2014-X5) （BYND2014-X5）
