食品科学2017，Vol.38Issue(3)：254-260,7.DOI:10.7506/spkx1002-6630-201703041
PPARγ调控脂肪细胞增殖和分化机理研究进展
Progress in the Knowledge of the Mechanism of PPAR Gamma Regulation of Adipocyte Proliferation and Differentiation
摘要
Abstract
With the improvement of living standards,long-term consumption of high calorie diet and physical inactivity result in storage of excess energy in the body in the form of fat,leading to obesity.Obesity has been officially listed as a chronic disease by the World Health Organization (WTO) in 1997.Peroxisome proliferator-activated receptors (PPARs) regulate the proliferation and differentiation of adipocytes by binding themselves with the trans-acting element of the target gene.Understanding the structural features,expression characteristics and mechanism of PPARs is of important theoretical significance and practical value for the control of obesity and related diseases.This article reviews the protein structure,gene expression and ligand activation of PPARγ,the interaction between different types of PPARs,and the role of PPAR7 in lipid metabolism and the differentiation of adipocytes by natural ligands.Strategies for the prevention of obesity are put forward based on adipocyte proliferation regulation by PPARγ.关键词
肥胖/转录因子/脂肪细胞/表达调控Key words
obesity/trans-acting elements/adipocyte/expression regulation分类
生物科学引用本文复制引用
杨谷良,潘敏雄,向福,叶辉,吴鹏,王书珍,李士明..PPARγ调控脂肪细胞增殖和分化机理研究进展[J].食品科学,2017,38(3):254-260,7.基金项目
国家自然科学基金面上项目(31571832) （31571832）
湖北省自然科学基金面上项目(06bm138) （06bm138）
湖北省教育厅自然科学基金青年项目(07bq013) （07bq013）
