中国食物与营养2017，Vol.23Issue(5)：59-63,5.
大强度运动导致肝脏线粒功能紊乱及姜黄素的拮抗效应
High-Intensity Excercise Induced Hepatic Mitochondrial Dysfunction in Mice and Protective Effects of Curcumin
摘要
Abstract
[Objective] To investigate the protective role of curcumin in intense swimming-triggered dysfunction focused on hepatic mitochondria.[Method] Adult male BALB/C mice were randomly divided into four groups including rested controls,intense exercise,intense exercise + curcumin (100 mg/kg body weight) and rested plus curcumin (100 mg/kg body weight) pretreatment.Curcumin was administrated for 4 weeks and intense exercise program (swimming for 90 min/d) was performed concurrently at the fourth week.Immediately upon final swimming,the mice were sacrificed.Serum alanine aminotransferase (ALT),aspartate transaminase (AST),and hepatic ultrastructural malformation were examined.Hepatic mitochondrial membrane potential (MMP) and respiratory control ratio (RCR) were measured.[Result] Compared to swimming group,curcumin intervention decreased intense swinmming-triggered the leakage of ALT (P ＜ 0.05) and AST (P ＜ 0.05) and hepatic ultrastructural malformation.Curcumin pretreatment evidently alleviated mitochondrial dysfunction by inhibiting the decline of membrane potential (P ＜ 0.05) and respiratory control ratio (P ＜ 0.05) in hepatic mitochondria of intense swimming mice.[Conclusion] Curcumin exhibited protective role in intense exercise-induced hepatic mitochondrial ultrastructural damage and dysfunction,highlighting a promising strategy for sports anti-fatigue by naturally occurring phytochemicals.关键词
姜黄素/大强度运动/线粒体/超微病理Key words
curcumin/intense exercise/mitochondria/ultrastructural pathology引用本文复制引用
高超,刘阳,王宇飞,张雪松,徐维盛,杨月欣..大强度运动导致肝脏线粒功能紊乱及姜黄素的拮抗效应[J].中国食物与营养,2017,23(5):59-63,5.基金项目
国家科技支撑计划(项目编号:2012BAD33B01) （项目编号:2012BAD33B01）
中国疾病预防控制中心营养与健康所青年科学基金(项目编号:NINH201606). （项目编号:NINH201606）
