现代食品科技2017，Vol.33Issue(6)：1-8,8.DOI:10.13982/j.mfst.1673-9078.2017.6.001
龙眼果肉提取物改善SAMP8小鼠学习记忆功能
Ameliorative Effect of Longan Pulp Extracts on the Learning and Memory Deficits in SAMP8 Mice
摘要
Abstract
The effect and mechanism of the petroleum ether fraction (LP) and aqueous fraction (LW) of ethanol extract of longan pulp on improving the learning and memory of SAMP8 mice were investigated.SAMP8 mice were used as a mouse model of Alzheimer's disease,and the Morris water maze test was used to evaluate their learning and memory.Nitric oxide (NO),malondialdehyde (MDA),and reduced glutathione (GSH) levels,superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in the serum,and the protein expression levels of amyloid-beta (Aβ1-42),amyloid precursor protein (APP),and beta-site APP cleaving enzyme 1 (BACE1) in the brains of mice were measured.The results showed that,compared to the model group,LP and LW could significantly ameliorate the learning and memory deficits in Alzheimer's model mice,decrease the serum NO and MDA content and the protein expression levels of Aβ1-42,APP,and BACE1 in the brain to various degrees,and enhance the activities of SOD and GSH-Px in the serum.These results indicate that both LP and LW of ethanol extract of longan pulp could ameliorate the learning and memory deficits in SAMP8 mice,through a combination of improved antioxidant activity and inhibition of the expression of Aβ and its relevant proteins in the brain,exhibiting the potential to prevent Alzheimer's disease.关键词
龙眼果肉/老年痴呆/学习记忆功能/抗氧化/β-淀粉样蛋白Key words
longan pulp/Alzheimer's disease/learning and memory/antioxidative ability/β-amyloid protein引用本文复制引用
冉玉兵,刘磊,张瑞芬,黄菲,魏振承,张名位..龙眼果肉提取物改善SAMP8小鼠学习记忆功能[J].现代食品科技,2017,33(6):1-8,8.基金项目
国家自然科学青年基金项目(31301459) （31301459）
国家重点研发计划(2016YFD0400702-2) （2016YFD0400702-2）
广东省自然科学基金项目(2014A030313568) （2014A030313568）
广东省省级科技计划项目(2016B070701012) （2016B070701012）
广州市珠江科技新星专项项目(201506010028) （201506010028）
广州市科技计划项目(201704020039) （201704020039）
